Foot-and-Mouth Disease (FMD) is caused by the Foot-and-mouth disease virus (FMDV), a single-stranded RNA virus belonging to the Aphthovirus genus within the Picornaviridae family. The disease is named for its characteristic lesions typically found on the mouth and hooves of affected animals.
FMD primarily infects cattle, swine, sheep, goats, water buffalo, and various wild cloven-hoofed animals, and it is not considered a typical zoonotic disease. Transmission routes include aerosols, direct contact, and contaminated environments. Clinical presentations commonly include vesicles on the oral cavity, tongue, and hooves, with infected swine frequently exhibiting lameness and a reluctance to move.
To address diverse FMD screening requirements, EBS provides the SentinelPlus FMDV Non-Structural Protein 3ABC Antibody Rapid Test, the 3ABC Antibody ELISA Kit, and the Sentinel FMDV Type O Structural Protein Antibody Rapid Test. These assays are engineered for distinct diagnostic scenarios, including Differentiating Infected from Vaccinated Animals (DIVA), routine antibody surveillance, and vaccine efficacy assessments.
Foot-and-Mouth Disease virus primarily targets cloven-hoofed animals, encompassing cattle, swine, sheep, goats, water buffalo, and various wild cloven-hoofed species. Human infections are exceptionally rare because FMDV has an extremely low affinity for human cells, generally resulting in no clinical symptoms. The very few documented human cases have presented as mild, self-limiting infections, meaning FMD is not classified as a typical zoonotic disease.
Transmission routes of Foot-and-Mouth Disease include:
Classic clinical symptoms are characterized by vesicles, commonly localized on the oral cavity, tongue, and hooves. Affected swine frequently present with lameness and a severe reluctance to move. Post-mortem lesions typically include oral ulcers, hoof vesicles, and myocarditis in piglets.
Common testing methods for Foot-and-Mouth Disease (FMD) include:
|
Diagnostic Target |
Products Name |
Intended Use |
|
NSP 3ABC Antibody |
SentinelPlus FMDV 3ABC Antibody Rapid Test Kit & 3ABC Antibody ELISA Kit |
Differentiate between infected and vaccinated animals (DIVA) |
|
SP Type O Antibody |
Sentinel FMDV SP Type O Antibody Rapid Test Kit |
Evaluate vaccine-induced immune response and protective immunity against Type O virus |
Our FMD diagnostic solutions are offered in both Lateral Flow Rapid Test and ELISA formats:
|
Product Categories |
Intended Use |
Key Features |
|
Rapid Diagnostic Tests |
FMDV 3ABC Antibody Rapid Test Kit & SP Type O Antibody Rapid Test Kit |
On-Site Preliminary Screening & Rapid Interpretation Needs |
|
Enzyme-Linked Immunosorbent Assay (ELISA) Kits |
FMDV 3ABC Antibody ELISA Kit |
Laboratory Testing, High-Throughput Screening & Antibody Surveillance |
Foot-and-Mouth Disease (FMD) must be differentiated from other diseases that cause vesicles or similar lesions, commonly including:
|
Diseases |
Pathogen |
|
Swine Vesicular Disease (SVD) |
SVD virus，Picornavirus |
|
Vesicular Stomatitis (VS) |
Vesicular stomatitis virus，Rhabdovirus |
|
Vesicular Exanthema of Swine (VES) |
Senecavirus A，Picornavirus |
|
Exudative Epidermitis (EE) |
Staphylococcus hyicus |
Foot-and-Mouth Disease (FMD) diagnostic results must be comprehensively evaluated by integrating multiple factors, including disease pathogenesis, sampling timelines, sample matrix quality, testing methodologies, biosecurity protocols, vaccination status, and specific on-site farming conditions. These diagnostic reagents are strictly intended for use by qualified veterinary and laboratory professionals in accordance with product inserts, standard operating procedures, and practical disease control requirements.
In instances involving farm biosecurity breaches, suspected outbreaks, or notifiable animal diseases, all containment and reporting protocols must strictly adhere to competent regulatory authorities and official veterinary guidelines.
Built on precision diagnostic technologies, we continuously develop innovative biomedical testing solutions to support the health of both people and animals.
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