Sentinel®FMDV NSP Ab Rapid test ( Swine)

 

Foot and mouth disease (FMD) is a highly contagious viral disease that affects both domesticated and wild cloven-hoofed animals, such as cattle, sheep, and pigs. The incubation period for FMD may range between 1 to 7 days. In extreme cases, this period may range from as little as 12 hours to a maximum of 14 days. Animals susceptible to the FMDV infection can be characterized by a vesicular condition of the buccal mucosa, feet, and mammary glands of females.

 

The foot-and-mouth disease virus (FMDV) is classified within the Picornaviridae family. There are seven different serotypes: A, O, C, Asia-1, SAT-1, SAT-2, SAT-3, where each serotype has several subtypes. However, infection of one serotype does not provide immunity against any other serotypes.

 

The rapid replication, infection, and symptom development of the highly contagious virus means that FMD can greatly affect economies on a global scale.

 

After FMDV infection, the virus will produce structural proteins (SPs) and non-structural proteins (NSPs). These proteins are both involved in further virus replication; the former form the viral particles, while the latter are specific to the replication process. As the virus replicates, NSPs will enter the blood circulation causing immune reactions and produce NSP antibodies.

 

Current commercial FMD vaccines on the market are often purified according to OIE requirements and all NSPs are removed. The detection of NSP antibodies of the FMDV can be used to identify past or present infection of all seven serotypes of the virus.

 

Therefore, the Sentinel® FMDV NSP Ab Rapid Test can be used to confirm suspected cases of FMD, to detect viral activity or confirm free from infection, and to certify animals for trade.